General Information

  • ID:  hor002939
  • Uniprot ID:  Q8T112
  • Protein name:  Cerebrin
  • Gene name:  CBPH
  • Organism:  Aplysia californica (California sea hare)
  • Family:  NA
  • Source:  animal
  • Expression:  Expressed only in cerebral ganglion.
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Aplysia (genus), Aplysiidae (family), Aplysioidea (superfamily), Aplysiida (order), Tectipleura, Euthyneura, Heterobranchia (subclass), Gastropoda (class), Mollusca (phylum), Lophotrochozoa, Spiralia, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  NA
  • GO BP:  NA
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  NGGTADALYNLPDLEKI
  • Length:  17
  • Propeptide:  MFGYRSLLVLLVTLSLCLLLQSSHCSAVRTYGNDLDARARREIISLAARLIKLSMYGPEDDSFVKRNGGTADALYNLPDLEKIGKR
  • Signal peptide:  MFGYRSLLVLLVTLSLCLLLQSSHCSA
  • Modification:  T17 Isoleucine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  May function as a hormone and may play a neuromodulatory role.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-Q9H1Z8-F1(AlphaFold_DB_ID)
  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
  •    AF-Q9H1Z8-F1.pdbhor002939_AF2.pdbhor002939_ESM.pdb

Physical Information

Mass: 208958 Formula: C79H126N20O28
Absent amino acids: CFHMQRSVW Common amino acids: L
pI: 3.88 Basic residues: 1
Polar residues: 6 Hydrophobic residues: 6
Hydrophobicity: -37.06 Boman Index: -2061
Half-Life: 1.4 hour Half-Life Yeast: 3 min
Half-Life E.Coli: >10 hour Aliphatic Index 103.53
Instability Index: -25.88 Extinction Coefficient cystines: 1490
Absorbance 280nm: 93.13

Literature

  • PubMed ID:  11413240
  • Title:  Cerebrin prohormone processing, distribution and action in Aplysia californica.